IMPROVING CANCER IMMUNOTHERAPY BY RATIONALLY COMBINING ONCOLYTIC VIRUS WITH MODULATORS TARGETING KEY SIGNALING PATHWAYS

Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways

Abstract Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer, with OV-elicited antitumor immunity being key to their overall therapeutic efficacy.Currently, the clinical effectiveness of OV as monotherapy remains limited, and thus investigators have been exploring various combinations with other anti-cancer agent

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INFLUENCE OF SOME PROCESS INPUT FACTORS ON THE SURFACE ROUGHNESS AMPLITUDE PARAMETERS AT EDM WHEN USING TUBULAR TOOL ELECTRODES

The electrical discharge machining could be used sometimes to improve the roughness of the machined surfaces.The values of the surface roughness parameters are affected by the characteristics of the electrical discharges developed between the closest asperities existing on the active surface of the tool electrode and on the workpiece surface to be

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